The Role of Family Genetics in Cancer Risk Assessment and Prevention

by | Jan 25, 2024 | Cancer Awareness

It’s natural to have a lot of questions if you’ve recently been diagnosed with cancer.

Ever think about why each of us is different? It’s because of our DNA – the special code that makes us who we are. Our DNA decides the health stuff we might face in our life journey, like dealing with not-so-friendly diseases, and one of them is the famous Cancer! So, let’s uncover the secrets of our DNA and the big fights it takes to keep us healthy! We’ll dig into the interesting world of genetics and find out why our family’s genetic history is so crucial. Understanding our family genetics can help us figure out and lower the chances of getting cancer. Let’s explore this cool science together!

What Is Hereditary Cancer?

A hereditary cancer syndrome means some people might have a higher chance of getting certain cancers because of genes passed down in families. This often happens when there are changes in certain genes that run in the family. It’s like having a special code in our genes that might make us more likely to get cancer.

For women, some common hereditary cancer syndromes include things like hereditary breast and ovarian cancer, Lynch syndrome, Cowden syndrome, and hereditary diffuse gastric cancer. These syndromes can make someone more likely to get certain types of cancer, and it often starts at an early age.

It’s all about inherited gene mutations passed down from parent to child within a family. Several factors may point to an increased risk:

Family History Of Cancer

If you have three or more relatives on the same side of the family with the same or related forms of cancer, it could suggest a higher risk.

Cancer At An Early Age

Having two or more relatives diagnosed with cancer at an early age may indicate an increased risk. Keep in mind that the definition of “early age” can vary depending on the type of cancer.

Multiple Cancers

If one relative develops two or more types of cancer, it could be a sign of hereditary risk.

Rare Cancers

Certain cancers, like ovarian cancer, adrenocortical cancer, or sarcoma, are linked to inherited genetic mutations.

To figure out if someone might be at a higher risk, doctors do something called a hereditary cancer risk assessment.

What is Genetic Cancer Risk Assessment (GCRA)?

This is like a health checkup that looks at personal and family history, along with other medical info. Doctors, especially those who take care of women’s health, like obstetricians and gynaecologists, usually do these assessments. It’s important to keep these checks up to date.

If the assessment shows a higher risk, the next step is to talk to a specialist in cancer genetics or someone who knows a lot about genes and health. They might suggest more tests, like genetic testing, to get a better idea of the risk. This could lead to a personalized plan for cancer screening or ways to lower the risk.

It’s interesting to know that having a gene mutation doesn’t guarantee that you’ll get cancer. For instance, a woman might have a 45% to 65% chance of developing breast cancer based on genetic testing, but she may never actually develop the disease. On the flip side, another woman with a lower percentage, say 25%, might end up facing breast cancer.

Can We Stop Cancer Before It Starts with Genetic Analysis?

Well, the answer might be yes! Genetic analysis checks for special codes in our genes that can make us more likely to get certain cancers. If we find out about these codes early on, we can take steps to be extra careful, like getting more check-ups or doing things to lower the risk.

Understanding our family genes is like having a secret weapon. It helps us see if there are health challenges ahead and gives us the power to do things that could prevent cancer.

Dr Sachin Marda, who leads the Genetic Cancer Risk Assessment (GCRA) at Yashoda Hospital works with other health experts and gene counsellors. They help people make smart choices about managing their risk of cancer.


In the end, here’s the takeaway: our family genes are like secret weapons in the battle against cancer. They’re a big part of figuring out how likely we are to face this challenge. By understanding the stories hidden in our family history, we can make smart choices about our health.


1. What is hereditary cancer, and how does it relate to family genetics?

Hereditary cancer occurs when there are changes in specific genes that run in families, making individuals more susceptible to certain cancers. Family genetics play a crucial role as certain gene mutations are passed down from parents to children. Factors like a strong family history of cancer, early-age diagnoses, and multiple rare cancers within the family can indicate an increased risk.

2. How does Genetic Cancer Risk Assessment (GCRA) work?

GCRA is like a health checkup that examines personal and family history, along with other medical information. Typically performed by healthcare professionals specializing in women’s health, it helps identify individuals at a higher risk of hereditary cancer. If the assessment indicates an elevated risk, further consultations with specialists in cancer genetics may lead to genetic testing, offering insights into personalized cancer screening or risk reduction strategies.

3. Can a gene mutation guarantee that an individual will develop cancer?

No, having a gene mutation doesn’t guarantee the development of cancer. Genetic testing can provide a percentage likelihood of developing certain cancers. For example, a woman with a specific gene mutation may have a 45% to 65% chance of developing breast cancer, but it doesn’t ensure that she will develop the disease. On the contrary, another woman with a lower percentage might still face cancer.

4. Can genetic analysis help prevent cancer before it starts?

Yes, genetic analysis looks for specific codes in our genes that may increase the likelihood of certain cancers. Early detection of these codes enables individuals to take proactive steps such as more frequent check-ups or adopting preventive measures to lower the risk. Understanding family genes becomes a valuable tool in predicting health challenges and empowering individuals to make informed choices.

5. How does understanding family genetics help us in the battle against cancer?

Family genes act as secret weapons in the fight against cancer by providing insights into the likelihood of facing this challenge. By understanding the stories hidden in our family history, we gain the knowledge needed to make informed decisions about our health. Genetic Cancer Risk Assessment, led by experts like Dr. Sachin Marda at Yashoda Hospital, serves as a resource for individuals to make smart choices in managing their risk of cancer.

Stay Ahead, Stay Healthy:

Avoid Hereditary Cancer with Genetic Cancer Risk Assessment (GCRA)

About Dr.Sachinmarda

"Dr. Sachin Marda is one of the best top leading award-winning renowned oncologists in Hyderabad and in India. He has 14 years of experience and treated more than 11000 patients till date. He completed his MS general surgery from Mumbai University in 2005 with a Gold medal and MCH Surgical Oncology in Gujarat University in 2009 with a First rank. He is also trained in UK with MRCS and in NCCS Singapore. He offers ethical, affordable complete cancer treatment with a holistic approach. He is specialised in all types of cancer treatment with laparoscopic, and robotic surgery. He has an extraordinary team with excellent knowledge in chemotherapy, radiation therapy, and targeted immunotherapy. His expertees in oral, stomach, breast. uterine, lung, prostate cancer"

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